Arsenal will be without midfielder Alex Oxlade-Chamberlain for their Champions League trip to Fenerbahce.
The 20-year-old suffered a knee injury in the 3-1 defeat by Aston Villa on Saturday, with boss Arsene Wenger declaring the England international will be out for up to six weeks.
Defenders Bacary Sagna, Kieran Gibbs and Nacho Monreal should all be fit for the play-off first leg in Turkey. The overall winners of the tie will enter the Champions League group stage.
“We fought very hard last season to be in the top four of the Premier League and that game has a vital importance,” said Frenchman Wenger.
“It is a consequence of what we tried to achieve last season and therefore, on the back of our defeat against Aston Villa, it’s important as well to bounce back straight away.
“To be part of the top level – that is the most important thing for us. All the rest are the consequences of it. When you are a football player, you want to play at the top level and that’s what the Champions League is about.”
Fenerbahce, though, are playing in the tie under the threat of a two-year ban from European competition for match-fixing.
They were handed the ban in June, but reinstated in this season’s Champions League while an appeal is heard.
That appeal will take place on 28 August, the day after the second leg against Arsenal at Emirates Stadium.
A decision on what would happen if Fenerbahce win the tie but lose their appeal is yet to be made.
Left-back Monreal missed the loss to Villa with a back problem, but Wenger said that the 27-year-old Spaniard came through training.
“Everybody else should make it,” said Wenger. “There’s a final decision (on Wednesday) but Sagna and Gibbs should be available.”